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Pioglitazone for lichen planopilaris Drug: Antirheumatic steroids Comments: Initial outcome in the study was favorable. However, patients treated with oral corticosteroids developed osteopenia subsequent development of osteoporosis. 43. Järvenpää et al. 2010 Study (JAV PROSPER, Finland) Population: Women aged ≥65 y Participants were randomly assigned to receive either 200 mg of melatonin and 75 plus 5 mg of prednisone, or their usual drug plus 5 mg of prednisone and 500 melatonin in twice daily divided doses (for 28 d total) for 16 months Intervention: Treatment with high dose melatonin plus prednisone (100 mg/d) or melatonin alone over 16 months Primary outcome: Clinical assessments of osteopenia and osteoporosis Secondary outcome: Hormonal measures (estrogen, progesterone, free testosterone, IGF-1, insulin, cortisol) best drugstore retinol cream for acne before and after trial Results: Mean baseline and treatment effects on biochemical markers were modestly and significantly different, despite a mean increase in melatonin dose from 6.6 to 10.9 μg/d. After 12 months, treatment with prednisone, melatonin, or their combination produced no Generic viagra in us significant change in biochemical markers. Melatonin plus prednisone also contributed to slight but non-significant reductions in serum cortisol levels, a marker of impaired cortisol production. However, after 2 years, in the patients who received prednisone, melatonin plus mean glucocorticoid concentrations were significantly higher than baseline (p < 0.05). Conclusions: Melatonin and prednisone are combined for maintenance of estrogen and a low cortisol dose in women suffering from osteoporosis. 44. Järvenpää et al. 2010 Study (JAV PROSPER, Finland) Population: Women aged ≥65 y Participants were randomly assigned to receive either 200 mg of melatonin and 75 plus 5 mg of prednisone, or their usual drug plus 5 mg of prednisone and 500 melatonin in twice daily divided doses (for Sildenafil tab dose 28 d total) for 12 months Intervention: Treatment with high generic finasteride 1mg vs propecia dose melatonin plus prednisone (100 mg/d) or melatonin alone over 12 months Primary outcome: Clinical assessments of osteopenia and osteoporosis Secondary outcome: Hormonal measures (estrogen, progesterone, free testosterone, IGF-1, insulin, cortisol) before and after trial Results: Mean baseline and treatment effects on biochemical markers were modestly and significantly different, although treatment.
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