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Trazodone for sleep long term (N = 35, t 48 7.8, p<.001, d = 1.3, 0.3). Participants used higher doses of naltrexone (mean 5.4 mg/d) as compared to placebo (mean of 5 mg/d). Discussion This is the first study to investigate acute and long-term effects of naltrexone on sleep quality. We observed significant effects of naltrexone on sleep parameters immediately after the administration of anti-anxiety medication, as well a reduction in sleep stages over the 2-week duration of trial. We had hypothesized that naltrexone would have an effect on sleep quality as compared to placebo, previous studies have found a positive effect of naltrexone on sleep quality in patients with PTSD.10 addition, online coupons canada drug pharmacy we observed that these effects occurred following the administration of anti-anxiety medication for a week. Naltrexone was administered to patients with treatment-resistant PTSD, who Trazodone 100mg $149.39 - $0.83 Per pill had not received prior antidepressant pharmacotherapy. Previous studies of the acute effects naltrexone in patients with PTSD have had mixed results. In one such study, naltrexone administered to 20 outpatients with PTSD showed a reduction in depression symptoms and an improvement in anxiety.11 However, the number of participants in this study was small, and its sample size was not statistically significant. Additionally, it lacked an 8-week follow up. Similarly, our study did not include a larger sample size to determine whether any effects of naltrexone over the 2 week study period would last. Additionally, our sample size did not include a control group, as study examining the effects of naltrexone on sleep quality at 6 months of treatment in a larger sample size was not conducted, although research suggests that inpatients undergoing pharmacological treatment for PTSD are at lower risk of developing a depressive episode compared to other populations of depression.12 We used large multi-center, randomized, double-blind, crossover design, and were able to maintain an inter-rater reliability of greater than 70%. The most prominent Nexium generic canada pharmacy finding of present study was that naltrexone decreased sleep stage N0 (N1-N3) and total sleep time in the first 3 h after administration. Sleep stage N0 is a measurement of overall sleep capacity, and is the most specific to physiological function of sleep.13 In terms a measurement of sleep quality, stage N0 has been suggested to be a good indicator of the quality sleep, and has been associated with decreased daytime functioning after stress exposure.13 Although previous studies examining the effect of naltrexone in patients with PTSD have reported a similar pattern of results, it should be noted that previous studies did not examine all patients for inclusion in the trial sample (eg)

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